Sıçanlarda Sodyum Valproat ile İndüklenen Dalak Toksisitesinde Rutinin Antioksidan, Antiinflamatuvar ve Antiapoptotik Etkileri

Aim: Long-term exposure to sodium valproate, an antiepileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with antioxidant, anti-inflammatory antiapoptotic found naturally many plants. In this study, we aimed investigate the of rutin, natural on valproate-induced spleen tissue damage. 
 Materials Methods: 35 male rats were divided into 5 groups as control, valproate+Rutin 50 100 groups. For 14 days, 500 mg/kg dose valproate or rutin administered oral gavage. On day 15, tissues removed biochemical methods, stress, inflammation apoptotic parameters analyzed histologic analysis was performed.
 Results: The levels apoptosis increased compared control group (p